New Mexico INBRE Specific Aims in Brief

(NM-INBRE 2014 – 2019)

1. Network leadership, organization, oversight, and communication

2. Student-focused experiences in biomedical and biobehavioral research

3. Sequencing & Bioinformatics Core (SBC)

4. Faculty development and scientific research projects (DRPP)

5. Collaboration

    a. multi-disciplinary collaborative and community-based research, and

    b. cooperate synergistically with NIGMS IDeA and

    c. other related programs at the state, regional and national level


New Mexico INBRE Specific Aims, Complete


1. Network leadership, organization, oversight, and communication

Aim 1a: The continuing successful management and operation and achievement of progress towards the long-term goals of the program will be accomplished through an experienced leadership team and highly capable staff.

Aim 1b: The established organizational structure and framework of formal policies, procedures and agreements in place will support continuing development and effective management of NM-INBRE as a dynamic and functional network.

Aim 1c: The Steering Committee will provide governance of the program through implementation of policies and operating procedures with effective representation of the priorities, interests, and internal perspectives of the individual participating network institutions.

Aim 1d: The External Advisory Committee will contribute scientific expertise in the thematic focus areas with direct responsibilities for the admission of investigators, assessment of progress, and guidance to ensure effective operation and longitudinal progress of the network towards achieving the goals of the program.

Aim 1e: Cohesive relationships and dissemination of information between network participants and institutions will be fostered through effective communications, organized meetings and conferences.

Aim 1f: Systematic program evaluation of the processes and outcomes will enable further development and improvements and contribute to the overall success of NM-INBRE. The Evaluation Plan will consist of both internal and external evaluation components, which combined will provide a comprehensive and systematic approach to assessing the effectiveness of the NM-INBRE in developing an institutional and statewide scientific network. Benchmarks and specific measures of assessment will be defined for each of the Aims 1-5 in this plan.


2. Student-focused experiences

Aim 2a: Student research experiences will be available through Developmental Research Projects.

Aim 2b: Formal programmatic undergraduate summer research experiences will be available for promising and highly qualified undergraduates.

Aim 2c: Inter-programmatic coordination of activities and effective partnering with other Training Workforce Development and Diversity (TWD) programs will facilitate the research training objectives.


3. Sequencing & Bioinformatics core (SBC)

Aim 3a: Advance cutting-edge knowledge discovery through innovative bioinformatics analysis techniques, resources, and tools. NGS is the first step in unlocking biologically-relevant discoveries. Mining and interpretation of the data are paramount. We will apply our robust array of bioinformatics resources, experience and skills to advance research in the network.

Aim 3b: Deliver and develop ground-breaking next-generation sequencing technologies and resources. NGS is transforming the genomics and transcriptomics landscape. We will leverage these resources, and use our knowledge and expertise to develop new techniques to accelerate research possibilities for the network.

Aim 3c: Engage the network in education and training through outreach, mentorships, internships, and symposia. There is great importance in training students in this rapidly developing field. Scientists and health professionals need to understand these emerging technologies in order to advance research and to deliver new prognostic and diagnostic techniques in the new field of personalized medicine. Our education plan is to develop bioinformatics-based pipeline initiatives for K-12, colleges, universities and teachers in the state of New Mexico and throughout the INBRE network, including seminars, workshops, consulting, mentorships and internships for faculty and students.

Aim 3d: Build and maintain research-enabling IT Infrastructure and mechanisms for communication within the network and to the public. The foundation of computationally-intensive bioinformatics, voluminous sequence data generation, remote collaboration and information sharing is a robust IT infrastructure. We will leverage and develop this resource to support the research goals of the network.


4. Faculty development, DRPP

Aim 4a:  The Developmental Research Project Program (DRPP) will support projects within the thematic research focus areas to address important biomedical questions and critical health problems. The thematic and crucial basic and translational research health focus areas targeted by the NM-INBRE Developmental Research Project Program (Brain and Behavioral Health; Cancer; Cardiovascular and Metabolic Diseases; Child Health; Environmental Health; Infectious Disease and Immunity) are strategic and enable inclusive participation from all of the network institutions to engage in research that benefits the health of our citizens and underserved communities.

Aim 4b:  The DRPP will use an efficient process for project application submission and review. A stepwise application process, with clear instructions and convenient web-based system for submission, will support participation from eligible faculty across the network. The selection process will involve a study section panel and NIH review criteria to identify the most promising scientific studies, strengthen the research capacity of the network, and increase the competitiveness of NM investigators for NIH research and training programs.

Aim 4c:  The DRPP mentoring program will facilitate faculty professional development. The scientific capabilities, academic progress and overall career development of Full Project Investigators will be fostered by through a formal mentoring program.

Aim 4d:  The DRPP will engage students and promote opportunities for research experiences. The portfolio of Full and Focus research projects will provide research experiences for undergraduate and graduate students in basic, clinical, translational and community based participatory research.

Aim 4e:  The maturation of scientific projects, professional development of investigators, and participation in the network will be assisted through annual assessment of progress. A process for annual reporting and progress review of research projects will be implemented to recognize accomplishments and achievements, identify challenges, needs, and areas for improvement, and enable programmatic interventions that maximize the potential for development of research capacity and training.


5. Collaboration

Aim 5a:  In partnership with other NIH programs in the State, the qualified personnel, resources and unique characteristics of the NM-INBRE network will be leveraged to increase the competitiveness of investigators, and enable productive multi-disciplinary clinical, translational and community-based research collaborations.

Aim 5b:  Inter-programmatic cooperation through the Mountain West Regional Research Consortium will provide opportunities for productive interactions, training and collaboration that contribute to the development of clinical and translational research capacity that benefits the health of our citizens and underserved communities.