Synthesis and Evaluation of Non-Natural (–)-CBD Analogs for Anti-Inflammatory Activity

Project Investigator:  William A. Maio

Project Description:  Neuroinflammation has emerged as a new focus area for Alzheimer’s disease (AD) research after being identified as contributing more to the pathogenesis of Alzheimer’s than senile plaques and neurofibrillary tangles themselves do. Significantly, in mouse models, it has been shown that a reduction of inflammation can reduce the buildup of neurotoxic substances over time, which is known to lead to neurodegeneration. Clearly, new drugs that can specifically target inflammation are needed and for decades, cannabinoids have been shown to possess potent anti-inflammatory activity. This project seeks to identify a potential lead compound derived from new organic substances that are structurally related to (–)-cannabidiol (CBD) – the major, non-psychoactive cannabinoid found in hemp which has recently emerged as a potent treatment option for the management of AD and related neurological disorders.

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